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Practitioner's Corner

J Investig Allergol Clin Immunol 2019; Vol. 29(5): 378-398

© 2019 Esmon Publicidad

Interestingly, only 8 patients presented symptoms of apple

allergy. Immunological analysis of Mal d 1 and Bet v 1 showed

that diversity of allergenicity was determined mainly by the

difference in allergen expression levels [8]. Bet v 1 homologs

of loquat and Mal d 1 were also considered to have different

expression levels. Further investigation of the differences

between the properties of the Bet v 1 homolog of loquat and

Mal d 1 is needed.

The limitations of this study included its small sample

size, especially with respect to patients who experienced

anaphylaxis. It is necessary to investigate more cases of

anaphylaxis to loquat in order to determine the exact protein

identities of possible allergens.

Our results indicated that the main allergen causing loquat

allergy was a Bet v 1 homolog with a sequence similar to that

of Mal d 1, but with a different immunoblot pattern. These

findings may contribute to the development of improved

prognostic and therapeutic tools for loquat allergy and loquat-

related anaphylaxis.


We are grateful for the support received from the following:

Dr. Takashi Arita of Ehime Seikyo Hospital, Department of

Pediatrics and Allergies; Dr. Nobue Takamatsu of Beppu

University, Faculty of Food Science and Nutrition; Dr. Makoto

Kameda of Osaka Habikino Medical Center, Department

of Pediatrics; and Dr. Satoshi Takada of Aichi Medical

University Hospital, Department of Pediatrics for the control

blood serum. We are also grateful to Miyuki Teshigawara, a

research assistant at Fujita Health University, for assistance

with experimental analyses.


Yasuto Kondo received funding from the Consumer


Conflicts of Interest

Kayoko Matsunaga belongs to an endowed department

sponsored by Hoyu Co., Ltd. The remaining authors declare

that they have no conflicts of interest.


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Manuscript received March 7, 2019; accepted for publication

April 23, 2019.

Yasuto Kondo

Department of Pediatrics, Fujita Health University

Bantane Hospital

3-6-10 Otobasi, Nakagawa, Nagoya, Aichi, 454-8509



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