Ahead of Print


Review

How Far Are We From Achieving Delabeling of False Penicillin/b-Lactam Allergy Alerts? A Population Problem
Tejedor-Alonso MA, Perez-Encinas M, Sanz Márquez S, Martinez Simon JJ, Moreno-Nuñez L, Gonzalez-Moreno A, Macias-Iglesias J, Rosado-Ingelmo A
J Investig Allergol Clin Immunol 2025; Vol. 35(1)
doi: 10.18176/jiaci.1004
[summary] [PDF full-Text]

Phenotyping Asthma Exacerbations: One Step Further in the Management of Severe Asthma
Ojanguren I, Quirce S, Bobolea I, Pérez de Llano L, Del Pozo V
J Investig Allergol Clin Immunol 2025; Vol. 35(1)
doi: 10.18176/jiaci.1043
[summary] [PDF full-Text]

Position Paper on the Treatment of Eosinophilic Esophagitis With Dupilumab
Tomás-Pérez M, Domenech-Witek J, Ávila-Castellano MR, Carballas-Vázquez C, Vásquez-Bautista AA, Jover-Cerdá V, González-Mendiola R
J Investig Allergol Clin Immunol 2025; Vol. 35(3)
doi: 10.18176/jiaci.1038
[summary] [PDF full-Text]

Original Articles

Influencing factors on the safety and effectiveness of venom immunotherapy
Arzt-Gradwohl L, Annik Herzog S, Aberer W, Alfaya Arias T, Antolín-Amérigo D, Bonadonna P, Boni E, Bożek A, Chełmińska M, Ernst B, Frelih N, Gawlik R, Gelincik A, Hawranek T, Hoetzenecker W, Jiménez Blanco A, Kita K, Kendirlinan R, Košnik M, Laipold K, Lang R, Marchi F, Mauro M, Nittner-Marszalska M, Poziomkowska-Gęsicka I, Pravettoni V, Preziosi D, Quercia O, Reider N, Rosiek-Biegus M, Ruiz-Leon B, Schrautzer C, Serrano P, Sin A, Ayşe Sin B, Stoevesandt J, Trautmann A, Vachová M, Johannes Sturm G
J Investig Allergol Clin Immunol 2025; Vol. 35(1)
doi: 10.18176/jiaci.0967
[summary] [PDF full-Text] [Supplemental Materials]

LAD2 mast cell activation test associates with the reaction severity and diagnoses BAT nonresponders in Hymenoptera venom allergy
Koren A, Dejanovic L, Kopac P, Erzen R, Bajrovic N, Zidarn M, Korosec P
J Investig Allergol Clin Immunol 2025; Vol. 35(1)
doi: 10.18176/jiaci.0969
[summary] [PDF full-Text] [Supplemental Materials]

Basophil activation test with progressively less heated forms of egg distinguishes egg allergic from tolerant children
De Vlieger L, Nuyttens L, Ieven T, Diels M, Coorevits L, Cremer J, Schrijvers R, Bullens DMA
J Investig Allergol Clin Immunol 2025; Vol. 35(2)
doi: 10.18176/jiaci.0964
[summary] [PDF full-Text] [Supplemental Materials]

Sunflower (Helianthus annuus) Seed Allergy
Galleani C, Diéguez MC, Cabanillas B, Martín-Arriscado Arroba C, Enríquez-Matas A, Crespo JF
J Investig Allergol Clin Immunol 2025; Vol. 35(1)
doi: 10.18176/jiaci.0965
[summary] [PDF full-Text]

Deep intronic 9q21.11 polymorphism contributes to atopic dermatitis risk through methylation regulated expression of tight junction protein 2
Eliza Lim YY, Yie Sio Y, Say YH, Reginald K, Tim Chew F
J Investig Allergol Clin Immunol 2025; Vol. 35(3)
doi: 10.18176/jiaci.0978
[summary] [PDF full-Text] [Supplemental Materials]

Differences in molecular sensitization profiles between a Spanish and Latin American mite allergic patients
Calzada D, Bartra J, Serrano CD, Riggioni S, Moran E, Maselli JP, Silva DL, Ramirez LF, Pascal M, Carnés J, Valero A
J Investig Allergol Clin Immunol 2025; Vol. 35(2)
doi: 10.18176/jiaci.0968
[summary] [PDF full-Text] [Supplemental Materials]

R-mandelonitrile-lyase, homolog to Pru d 10, is a major peach allergen in peach allergic Spanish population
López-Matas MA, Vílchez-Sánchez F, Álvarez F, Rodriguez-Perez R, Dominguez-Ortega J, Carnes J, Pedrosa M
J Investig Allergol Clin Immunol 2025; Vol. 35(2)
doi: 10.18176/jiaci.0972
[summary] [PDF full-Text]

Investigating Novel Food Sensitization: A Real-Life Prevalence Study of Cricket, Locust, and Mealworm IgE-Reactivity in Naïve allergic Individuals
Scala E, Abeni D, Villella V, ViIlalta D, Cecchi L, Caprini E, Asero R
J Investig Allergol Clin Immunol 2025; Vol. 35(3)
doi: 10.18176/jiaci.0986
[summary] [PDF full-Text] [Supplemental Materials]

Mast Cell Activation Profile and TFH13 Detection Discriminate Food Anaphylaxis Versus Sensitization
Ollé L, García-García L, Ruano M, Bartra J, González-Navarro EA, Pérez M, Roca-Ferrer J, Pasca MI, Martín M, Muñoz-Cano R
J Investig Allergol Clin Immunol 2025; Vol. 35(3)
doi: 10.18176/jiaci.0995
[summary] [PDF full-Text] [Supplemental Materials]

Pharmacokinetics and Safety of Bilastine 10 mg/d in Children Aged 2 to 5 Years With Allergic Rhinoconjunctivitis or Urticaria: A Phase 3 Clinical Trial
Majorek-Olechowska B, Slomskis T, Zollerová L, Martín I, Sánchez C, Gilaberte I, Arranz P, on behalf of the BILA-4021/PED Research Group
J Investig Allergol Clin Immunol 2025; Vol. 35(4)
doi: 10.18176/jiaci.1003
[summary] [PDF full-Text] [Supplemental Materials]

Fecal IgE Analyses Reveal a Role for Stratifying Peanut-Allergic Patients
Czolk R, Codreanu-Morel F, de Nies L, Busi SB, Halder R, Hunewald O, Boehm TM, Hefeng FQ, De Beaufort C, Wilmes P, Ollert M, Kuehn A
J Investig Allergol Clin Immunol 2025; Vol. 35(4)
doi: 10.18176/jiaci.1008
[summary] [PDF full-Text] [Supplemental Materials]

Longitudinal Follow-up Reveals Peripheral Immunological Changes Upon Tick Bite in a-Gal-Sensitized Individuals
Swiontek K, Fischer J, Hedin F, Revets D, Riel S, Chakrapani N, Mackenstedt U, Biedermann T, Kuehn A, Cosma A, Ollert M, Hilger C
J Investig Allergol Clin Immunol 2025; Vol. 35(4)
doi: 10.18176/jiaci.1028
[summary] [PDF full-Text] [Supplemental Materials]

Study of Urinary Protein Biomarkers in Hereditary Angioedema
Wu J, Tang X, Zhou N, Wang X, Liu P, Zhang Z, Zhang S, Zhi Y
J Investig Allergol Clin Immunol 2025; Vol. 35(5)
doi: 10.18176/jiaci.1032
[summary] [PDF full-Text] [Supplemental Materials]

Practitioner's Corner

Short Communications

Characteristics of Asthma Patients Admitted to the Intensive Care Unit of a Tertiary University Hospital in Madrid, Spain: A 5-Year Experience
Lozano-Espinosa M, Rodríguez-Otero N, Antolín-Amérigo D, Gordo Vidal F, Muriel A, de Pablo R, Quirce S
J Investig Allergol Clin Immunol 2025; Vol. 35(1)
doi: 10.18176/jiaci.1021
[summary] [PDF full-Text] [Supplemental Materials]

A Fully Human Monoclonal Antibody Isolated From a Beekeeper Targets the Immunodominant IgE Epitope of Api m 10
Lund A, Dorn B, Jakob T, Christensen LH, Jabs F, Spillner E
J Investig Allergol Clin Immunol 2025; Vol. 35(1)
doi: 10.18176/jiaci.1029
[summary] [PDF full-Text] [Supplemental Materials]

Tezepelumab in Patients With Severe Asthma: Response at 3 Months
Miralles-López JC, Andújar-Espinosa R, Bravo-Gutierrez FJ, Cabrejos-Perotti S, Ramírez-Hernández M, Díaz-Chantar C, Pajarón-Fernández MJ, Valverde-Molina J, Pérez-Fernández V, RE-ASGRAMUR GROUP
J Investig Allergol Clin Immunol 2025; Vol. 35(2)
doi: 10.18176/jiaci.1041
[summary] [PDF full-Text] [Supplemental Materials]

Stability of Asthma Phenotypes in the Spanish Cohort of the MEGA Project
Rial MJ, Betancor D, Cañas JA, Olaguibel JM, Rodrigo-Muñoz JM, Alvarez-Puebla MJ, Arismendi E, Barroso B, Bobolea I, Cárdaba B, Cruz MJ, Curto E, Del Pozo V, Domínguez-Ortega J, García de la Fuente A, González-Barcala FJ, Luna-Porta JA, Martínez-Rivera C, Mullol J, Muñoz X, Picado C, Plaza V, Quirce S, Soto-Retes L, Valverde-Monge M, Sastre J
J Investig Allergol Clin Immunol 2025; Vol. 35(1)
doi: 10.18176/jiaci.1026
[summary] [PDF full-Text] [Supplemental Materials]

Drug-induced Kounis Syndrome: A Retrospective Pharmacovigilance Study from the FAERS and JADER Databases
Li H, Liu Y, Tan L, Hu C, Su L
J Investig Allergol Clin Immunol 2025; Vol. 35(2)
doi: 10.18176/jiaci.1039
[summary] [PDF full-Text] [Supplemental Materials]

A 1-Bag/4-Step Rapid Desensitization Protocol to Reintroduce Agalsidase a in a Patient With Fabry Disease
Jimenez-Rodriguez TW, Soriano Gomis V, Burgos San-José A, Montoyo Antón RA, González Delgado MP, Gallego Velez CP, Ortolano S, Fernández J, Sánchez Martínez R
J Investig Allergol Clin Immunol 2025; Vol. 35(2)
doi: 10.18176/jiaci.1044
[summary] [PDF full-Text] [Supplemental Materials]

Case Reports

Nonmandatory Labeled Legumes Are an Emergent Safety Concern: An Illustrative Case Report
Vera-Berrios RN, Uriarte Vega L, Marco-Martín G, Fernández-Rivas M
J Investig Allergol Clin Immunol 2025; Vol. 35(1)
doi: 10.18176/jiaci.1020
[summary] [PDF full-Text]

Exercise-Dependent Codfish Allergy due to Tropomyosin
Faihs V, Kugler C, Eberlein B, Bent R, Darsow U, Boehm TM, Hilger C, Biedermann T, Kuehn A, Brockow K
J Investig Allergol Clin Immunol 2025; Vol. 35(1)
doi: 10.18176/jiaci.1022
[summary] [PDF full-Text] [Supplemental Materials]

Allergy to Red Mullet and Seabass: Two Newly Identified Red Mullet Allergens
Escalante-Carrero MD, Renilla-Arroyo JM, Fernández C, Martínez-Botas J, Antolín-Amérigo D, De la Hoz-Caballer B
J Investig Allergol Clin Immunol 2025; Vol. 35(1)
doi: 10.18176/jiaci.1024
[summary] [PDF full-Text] [Supplemental Materials]

Are Biosimilars of Biologics the Same as the Reference Drug in Terms of Allergy? Selective Allergy to Tocilizumab Biosimilar
Betancor D, Gómez-López A, Barroso B, Valverde-Monge M, Cañas JA, Rodrigo-Muñoz JM, Del Pozo V, Sastre J
J Investig Allergol Clin Immunol 2025; Vol. 35(1)
doi: 10.18176/jiaci.1025
[summary] [PDF full-Text] [Supplemental Materials]

Ozenoxacin-Induced Contact Dermatitis With Tolerance to Ciprofloxacin
Otero-Fernández MN, Laffond-Yges E, Castillo-Loja RM, Cabrera-Núñez A, Mazoteras-Martínez ME, Muñoz-Bellido FJ, Dávila I
J Investig Allergol Clin Immunol 2025; Vol. 35(1)
doi: 10.18176/jiaci.1031
[summary] [PDF full-Text]

Anaphylaxis Caused by a Mouse Bite in a Laboratory Researcher
Dager-García SA, Germán-Sánchez A, Pineda de la Losa F, Ferrer Franco AM
J Investig Allergol Clin Immunol 2025; Vol. 35(2)
doi: 10.18176/jiaci.1040
[summary] [PDF full-Text] [Supplemental Materials]

ATAK Complex Induced by Ranitidine: A Comprehensive Concept for Cardiac Involvement in Allergic Reactions
Lopez-Raigada A, Vega F, Múgica MV, Lopez-Sanz C, Alfranca A, Blanco C
J Investig Allergol Clin Immunol 2025; Vol. 35(2)
doi: 10.18176/jiaci.1042
[summary] [PDF full-Text]

Unveiling the Immunological Mechanism Underlying a Cutaneous Adverse Reaction to Enfortumab Vedotin: A Case Report Based on the Lymphocyte Transformation Test
Gutiérrez-Canales P, Fernández-Lozano C, Alba-Pérez V, Ruiz-Granados A, Díaz-Montalvo L, Martínez-Botas J, Solano-Solares E
J Investig Allergol Clin Immunol 2025; Vol. 35(1)
doi: 10.18176/jiaci.1023
[summary] [PDF full-Text]

Armelline Almond Allergy: The First Reported Case
Alessi L, Cirrincione S, Aiuto B, Gosso E, Cavallarin L, Giuffrida MG, Monti G, Lamberti C
J Investig Allergol Clin Immunol 2025; Vol. 35(1)
doi: 10.18176/jiaci.1033
[summary] [PDF full-Text] [Supplemental Materials]

Two Nonimmediate Reactions to Oxaliplatin and Docetaxel Confirmed by Lymphocyte Transformation Test and Treated With Successful Rapid Desensitization Procedures
Berges-Gimeno MP, Barra-Castro A, Fernandez- Lozano C, Solano-Solares E, Martinez-Jañez N, Pueyo- Lopez C, Martínez-Botas J
J Investig Allergol Clin Immunol 2025; Vol. 35(1)
doi: 10.18176/jiaci.1030
[summary] [PDF full-Text]

Letters to the Editor

Occupational Asthma and Rhinoconjunctivitis due to Soybean in a Bakery Worker
Özdemir Ö
J Investig Allergol Clin Immunol 2025; Vol. 35(2)
doi: 10.18176/jiaci.1035
[summary] [PDF full-Text]

Fatal CAEBV-Associated Vasculitis in ICF Syndrome Type 2
Shigemura T, Kobayashi N, Uehara T, Nakazawa Y
J Investig Allergol Clin Immunol 2025; Vol. 35(2)
doi: 10.18176/jiaci.1037
[summary] [PDF full-Text] [Supplemental Materials]

Effectiveness of Biologics in Patients With Severe Asthma and Psychiatric Comorbidities
Mascaró-Hereza B, Loli-Ausejo D, Valero A, Arismendi E, Bobolea I
J Investig Allergol Clin Immunol 2025; Vol. 35(2)
doi: 10.18176/jiaci.1034
[summary] [PDF full-Text]

Component-Based Assessment of the Main Allergens in Honeybee Venom in a Spanish Allergic Population
Carballada González F, Abel-Fernández E, González Guzmán LA, Pineda de la Losa F
J Investig Allergol Clin Immunol 2025; Vol. 35(3)
doi: 10.18176/jiaci.1050
[summary] [PDF full-Text] [Supplemental Materials]