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Review

Impact of climate change-related environmental factors on the allergens production and the epidemiology and severity of allergic pathologies
Montoro J, Antolín-Amérigo D, Artés M, Izquierdo-Domínguez A, Zapata JJ, Mur P, Carrillo T, Antépara I, Feo F, Moral A, Valero A
J Investig Allergol Clin Immunol 2024; Vol. 34(6)
doi: 10.18176/jiaci.0988
[summary] [PDF full-Text] [Supplemental Materials]

How Far Are We From Achieving Delabeling of False Penicillin/b-Lactam Allergy Alerts? A Population Problem
Tejedor-Alonso MA, Perez-Encinas M, Sanz Márquez S, Martinez Simon JJ, Moreno-Nuñez L, Gonzalez-Moreno A, Macias-Iglesias J, Rosado-Ingelmo A
J Investig Allergol Clin Immunol 2025; Vol. 35(1)
doi: 10.18176/jiaci.1004
[summary] [PDF full-Text]

Pathophysiology of De Novo Food Allergies After Solid Organ Transplant in Pediatric Patients
Pérez-López P, López-Guillén JL
J Investig Allergol Clin Immunol 2024; Vol. 34(6)
doi: 10.18176/jiaci.1027
[summary] [PDF full-Text]

Original Articles

Validation of Visual Analogue Scale for loss of smell as a quick test in chronic rhinosinusitis with nasal polyps
Alobid I, Calvo-Henríquez C, Viveros-Díez P, López-Chacón M, Rojas-Lechuga MJ, Langdon C, Marin C, Mullol J
J Investig Allergol Clin Immunol 2024; Vol. 34(6)
doi: 10.18176/jiaci.0937
[summary] [PDF full-Text]

Bilastine 0.6% preservative-free eye drops, an effective once-daily treatment to reduce signs and symptoms of allergic conjunctivitis: A pooled analysis of two randomized clinical trials
Gomes PJ, Ciolino JB, Arranz P, Gonzalo A, Fernández N, Hernández G
J Investig Allergol Clin Immunol 2024; Vol. 34(6)
doi: 10.18176/jiaci.0940
[summary] [PDF full-Text]

Clinical management of plant food allergy in patients sensitized to lipid transfer proteins is heterogeneous: identifying the gaps
García BE, Mateo-Borrega MB, Garrido S, D’Amelio CM, Compés E, Villareal O, García-Núñez I, Goikoetxea MJ
J Investig Allergol Clin Immunol 2024; Vol. 34(6)
doi: 10.18176/jiaci.0947
[summary] [PDF full-Text] [Supplemental Materials]

Influencing factors on the safety and effectiveness of venom immunotherapy
Arzt-Gradwohl L, Annik Herzog S, Aberer W, Alfaya Arias T, Antolín-Amérigo D, Bonadonna P, Boni E, Bożek A, Chełmińska M, Ernst B, Frelih N, Gawlik R, Gelincik A, Hawranek T, Hoetzenecker W, Jiménez Blanco A, Kita K, Kendirlinan R, Košnik M, Laipold K, Lang R, Marchi F, Mauro M, Nittner-Marszalska M, Poziomkowska-Gęsicka I, Pravettoni V, Preziosi D, Quercia O, Reider N, Rosiek-Biegus M, Ruiz-Leon B, Schrautzer C, Serrano P, Sin A, Ayşe Sin B, Stoevesandt J, Trautmann A, Vachová M, Johannes Sturm G
J Investig Allergol Clin Immunol 2025; Vol. 35(1)
doi: 10.18176/jiaci.0967
[summary] [PDF full-Text] [Supplemental Materials]

LAD2 mast cell activation test associates with the reaction severity and diagnoses BAT nonresponders in Hymenoptera venom allergy
Koren A, Dejanovic L, Kopac P, Erzen R, Bajrovic N, Zidarn M, Korosec P
J Investig Allergol Clin Immunol 2025; Vol. 35(1)
doi: 10.18176/jiaci.0969
[summary] [PDF full-Text] [Supplemental Materials]

Basophil activation test with progressively less heated forms of egg distinguishes egg allergic from tolerant children
De Vlieger L, Nuyttens L, Ieven T, Diels M, Coorevits L, Cremer J, Schrijvers R, Bullens DMA
J Investig Allergol Clin Immunol 2025; Vol. 35(2)
doi: 10.18176/jiaci.0964
[summary] [PDF full-Text] [Supplemental Materials]

Sunflower (Helianthus annuus) Seed Allergy
Galleani C, Diéguez MC, Cabanillas B, Martín-Arriscado Arroba C, Enríquez-Matas A, Crespo JF
J Investig Allergol Clin Immunol 2025; Vol. 35(1)
doi: 10.18176/jiaci.0965
[summary] [PDF full-Text]

Deep intronic 9q21.11 polymorphism contributes to atopic dermatitis risk through methylation regulated expression of tight junction protein 2
Eliza Lim YY, Yie Sio Y, Say YH, Reginald K, Tim Chew F
J Investig Allergol Clin Immunol 2025; Vol. 35(3)
doi: 10.18176/jiaci.0978
[summary] [PDF full-Text] [Supplemental Materials]

Differences in molecular sensitization profiles between a Spanish and Latin American mite allergic patients
Calzada D, Bartra J, Serrano CD, Riggioni S, Moran E, Maselli JP, Silva DL, Ramirez LF, Pascal M, Carnés J, Valero A
J Investig Allergol Clin Immunol 2025; Vol. 35(2)
doi: 10.18176/jiaci.0968
[summary] [PDF full-Text] [Supplemental Materials]

R-mandelonitrile-lyase, homolog to Pru d 10, is a major peach allergen in peach allergic Spanish population
López-Matas MA, Vílchez-Sánchez F, Álvarez F, Rodriguez-Perez R, Dominguez-Ortega J, Carnes J, Pedrosa M
J Investig Allergol Clin Immunol 2025; Vol. 35(2)
doi: 10.18176/jiaci.0972
[summary] [PDF full-Text]

Investigating Novel Food Sensitization: A Real-Life Prevalence Study of Cricket, Locust, and Mealworm IgE-Reactivity in Naïve allergic Individuals
Scala E, Abeni D, Villella V, ViIlalta D, Cecchi L, Caprini E, Asero R
J Investig Allergol Clin Immunol 2025; Vol. 35(3)
doi: 10.18176/jiaci.0986
[summary] [PDF full-Text] [Supplemental Materials]

Mast Cell Activation Profile and TFH13 Detection Discriminate Food Anaphylaxis Versus Sensitization
Ollé L, García-García L, Ruano M, Bartra J, González-Navarro EA, Pérez M, Roca-Ferrer J, Pasca MI, Martín M, Muñoz-Cano R
J Investig Allergol Clin Immunol 2025; Vol. 35(3)
doi: 10.18176/jiaci.0995
[summary] [PDF full-Text] [Supplemental Materials]

Pharmacokinetics and Safety of Bilastine 10 mg/d in Children Aged 2 to 5 Years With Allergic Rhinoconjunctivitis or Urticaria: A Phase 3 Clinical Trial
Majorek-Olechowska B, Slomskis T, Zollerová L, Martín I, Sánchez C, Gilaberte I, Arranz P, on behalf of the BILA-4021/PED Research Group
J Investig Allergol Clin Immunol 2025; Vol. 35(4)
doi: 10.18176/jiaci.1003
[summary] [PDF full-Text] [Supplemental Materials]

Fecal IgE Analyses Reveal a Role for Stratifying Peanut-Allergic Patients
Czolk R, Codreanu-Morel F, de Nies L, Busi SB, Halder R, Hunewald O, Boehm TM, Hefeng FQ, De Beaufort C, Wilmes P, Ollert M, Kuehn A
J Investig Allergol Clin Immunol 2025; Vol. 35(4)
doi: 10.18176/jiaci.1008
[summary] [PDF full-Text] [Supplemental Materials]

Longitudinal Follow-up Reveals Peripheral Immunological Changes Upon Tick Bite in a-Gal-Sensitized Individuals
Swiontek K, Fischer J, Hedin F, Revets D, Riel S, Chakrapani N, Mackenstedt U, Biedermann T, Kuehn A, Cosma A, Ollert M, Hilger C
J Investig Allergol Clin Immunol 2025; Vol. 35(4)
doi: 10.18176/jiaci.1028
[summary] [PDF full-Text]

Practitioner's Corner

Short Communications

Concomitant Efficacy of Dupilumab in Treating Eosinophilic Esophagitis and Type 2 Asthma
Tomás-Pérez M, Trisán Alonso A, Montoro-Ferrer A, Dominguez-Ortega J, Galindo-Bonilla PA, Clar Castelló M, Naves JE, Ausín P
J Investig Allergol Clin Immunol 2024; Vol. 34(6)
doi: 10.18176/jiaci.1011
[summary] [PDF full-Text]

Determinants of Disease Activity in Adults With Hereditary Angioedema due to C1-Esterase Inhibitor Deficiency
Lluncor-Salazar M, Phillips-Anglés E, Pedrosa M, Lamacchia D, Hernanz A, Prior N, Cabañas R, Caballero T
J Investig Allergol Clin Immunol 2024; Vol. 34(6)
doi: 10.18176/jiaci.1009
[summary] [PDF full-Text] [Supplemental Materials]

Gastrointestinal Symptoms: Under the Tip of the Iceberg in Lipid Transfer Protein Food Allergy
Ruano-Zaragoza M, Araujo-Sanchez G, Gelis S, Loli- Ausejo D, Mir-Ihara P, Mascaró-Hereza B, Sánchez- Fernández MC, Pascal M, Muñoz-Cano R, Bartra J
J Investig Allergol Clin Immunol 2024; Vol. 34(6)
doi: 10.18176/jiaci.1006
[summary] [PDF full-Text] [Supplemental Materials]

Impact of Allergic Rhinitis on Academic Performance in Adolescents and Adults: a Bayesian Analysis of MASK-air® Real-world Direct Patient Data
Vieira RJ, Pereira AM, Papadopoulos NG, Zuberbier T, Pham-Thi N, Giovannini M, Melén E, Azevedo LF, Fonseca JA, Bousquet J, Sousa-Pinto B
J Investig Allergol Clin Immunol 2024; Vol. 34(6)
doi: 10.18176/jiaci.1010
[summary] [PDF full-Text]

Safety, Tolerability, and Feasibility of the Milk Ladder for Reintroduction of Cow’s Milk in Infants With IgE-Mediated Cow’s Milk Allergy
Cerecedo I, de la Hoz B, Infante S, Freundt Serpa NP, Vaquero Rey A, Carrón Herrero A, Vázquez Cortés S, Garban Camero A, Redondo Vegas E, Gonzalo-Fernández A, Serrano García I, López-Picado A, Fernández-Rivas M
J Investig Allergol Clin Immunol 2024; Vol. 34(6)
doi: 10.18176/jiaci.1017
[summary] [PDF full-Text]

Characteristics of Asthma Patients Admitted to the Intensive Care Unit of a Tertiary University Hospital in Madrid, Spain: A 5-Year Experience
Lozano-Espinosa M, Rodríguez-Otero N, Antolín-Amérigo D, Gordo Vidal F, Muriel A, de Pablo R, Quirce S
J Investig Allergol Clin Immunol 2025; Vol. 35(1)
doi: 10.18176/jiaci.1021
[summary] [PDF full-Text]

A Fully Human Monoclonal Antibody Isolated From a Beekeeper Targets the Immunodominant IgE Epitope of Api m 10
Lund A, Dorn B, Jakob T, Christensen LH, Jabs F, Spillner E
J Investig Allergol Clin Immunol 2025; Vol. 35(1)
doi: 10.18176/jiaci.1029
[summary] [PDF full-Text]

Case Reports

Successful Desensitization to Tezepelumab in a Polysorbate-Allergic Patient
Bautista-Villanueva S, Mateos-Salvador M, Arrojo Fuentes R, Rial MJ
J Investig Allergol Clin Immunol 2024; Vol. 34(6)
doi: 10.18176/jiaci.1007
[summary] [PDF full-Text]

Eosinophilic Granulomatosis With Polyangiitis Triggered by an Arthropod Bite and Complicated by Renal and Hepatic Infarction and Pulmonary Embolism: A Case Report
Yu Y, Wang H, Weng W, Ma L
J Investig Allergol Clin Immunol 2024; Vol. 34(6)
doi: 10.18176/jiaci.1013
[summary] [PDF full-Text] [Supplemental Materials]

Hypersensitivity to Bismuth Subcitrate
Andrés-López B, Dordal Culla MT, Lleonart Bellfill R
J Investig Allergol Clin Immunol 2024; Vol. 34(6)
doi: 10.18176/jiaci.1018
[summary] [PDF full-Text]

Allergy to White Perilla and Cross-reactivity With Sesame
Ramírez-Mateo E, Elías-Sáenz I, Fernández-Lozano C, Carrón-Herrero A, Solano-Solares E, González-De-Olano D
J Investig Allergol Clin Immunol 2024; Vol. 34(6)
doi: 10.18176/jiaci.1016
[summary] [PDF full-Text]

Cross-reactivity to Hydroxypropyl Methylcellulose and Hydroxyethyl Cellulose in a Patient Allergic to Carboxymethylcellulose: A Case Report
Méar A, Babin M, Tisserand F, André C, Beriziky P, Maillard H
J Investig Allergol Clin Immunol 2024; Vol. 34(6)
doi: 10.18176/jiaci.1019
[summary] [PDF full-Text]

Nonmandatory Labeled Legumes Are an Emergent Safety Concern: An Illustrative Case Report
Vera-Berrios RN, Uriarte Vega L, Marco-Martín G, Fernández-Rivas M
J Investig Allergol Clin Immunol 2025; Vol. 35(1)
doi: 10.18176/jiaci.1020
[summary] [PDF full-Text]

Exercise-Dependent Codfish Allergy due to Tropomyosin
Faihs V, Kugler C, Eberlein B, Bent R, Darsow U, Boehm TM, Hilger C, Biedermann T, Kuehn A, Brockow K
J Investig Allergol Clin Immunol 2025; Vol. 35(1)
doi: 10.18176/jiaci.1022
[summary] [PDF full-Text]

Allergy to Red Mullet and Seabass: Two Newly Identified Red Mullet Allergens
Escalante-Carrero MD, Renilla-Arroyo JM, Fernández C, Martínez-Botas J, Antolín-Amérigo D, De la Hoz-Caballer B
J Investig Allergol Clin Immunol 2025; Vol. 35(1)
doi: 10.18176/jiaci.1024
[summary] [PDF full-Text]

Are Biosimilars of Biologics the Same as the Reference Drug in Terms of Allergy? Selective Allergy to Tocilizumab Biosimilar
Betancor D, Gómez-López A, Barroso B, Valverde-Monge M, Cañas JA, Rodrigo-Muñoz JM, Del Pozo V, Sastre J
J Investig Allergol Clin Immunol 2025; Vol. 35(1)
doi: 10.18176/jiaci.1025
[summary] [PDF full-Text] [Supplemental Materials]

Ozenoxacin-Induced Contact Dermatitis With Tolerance to Ciprofloxacin
Otero-Fernández MN, Laffond-Yges E, Castillo-Loja RM, Cabrera-Núñez A, Mazoteras-Martínez ME, Muñoz-Bellido FJ, Dávila I
J Investig Allergol Clin Immunol 2025; Vol. 35(1)
doi: 10.18176/jiaci.1031
[summary] [PDF full-Text]

Letters to the Editor

Adolescents and Vaping: The Essentials
Hernández-Suárez HR, Bartha I, Lasa-Luaces E, Rodríguez-Álvarez M, Garriga-Baraut T
J Investig Allergol Clin Immunol 2024; Vol. 34(6)
doi: 10.18176/jiaci.1014
[summary] [PDF full-Text]

Occupational Asthma and Rhinoconjunctivitis due to Soybean in a Bakery Worker
Özdemir Ö
J Investig Allergol Clin Immunol 2025; Vol. 35(2)
doi: 10.18176/jiaci.1035
[summary] [PDF full-Text]