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Review

Position Paper on the Treatment of Eosinophilic Esophagitis With Dupilumab
Tomás-Pérez M, Domenech-Witek J, Ávila-Castellano MR, Carballas-Vázquez C, Vásquez-Bautista AA, Jover-Cerdá V, González-Mendiola R
J Investig Allergol Clin Immunol 2025; Vol. 35(3)
doi: 10.18176/jiaci.1038
[summary] [PDF full-Text]

Spanish Consensus on the Diagnosis and Management of Patients With Activated PI3K Delta Syndrome (APDS)
Neth O, Alsina L, Rivière JG, López-Granados E, Seoane-Reula ME, González Granado LI, Sánchez-Ramón S, Rodríguez-Gallego C, Spanish APDS Study Group
J Investig Allergol Clin Immunol 2025; Vol. 35(2)
doi: 10.18176/jiaci.1059
[summary] [PDF full-Text] [Supplemental Materials]

Climate Change-Associated Environmental Factors and Pollutants: Impact on Allergic Diseases, Epidemiology, Severity, and Health Care Burden
Montoro J, Antolín-Amérigo D, Izquierdo-Domínguez A, Zapata JJ, García-Gallardo MV, González R, Armentia A, Rondón C, Fernández MM, Pedrero SG, Valero A
J Investig Allergol Clin Immunol 2025; Vol. 35(4)
doi: 10.18176/jiaci.1067
[summary] [PDF full-Text] [Supplemental Materials]

The Evolving Role of Lung Function Interpretation: Clinical Implications of the new ERS/ATS Standards in Asthma Care
García-Rio F
J Investig Allergol Clin Immunol 2025; Vol. 35(2)
doi: 10.18176/jiaci.1084
[summary] [PDF full-Text]

Original Articles

Basophil activation test with progressively less heated forms of egg distinguishes egg allergic from tolerant children
De Vlieger L, Nuyttens L, Ieven T, Diels M, Coorevits L, Cremer J, Schrijvers R, Bullens DMA
J Investig Allergol Clin Immunol 2025; Vol. 35(2)
doi: 10.18176/jiaci.0964
[summary] [PDF full-Text] [Supplemental Materials]

Deep intronic 9q21.11 polymorphism contributes to atopic dermatitis risk through methylation regulated expression of tight junction protein 2
Eliza Lim YY, Yie Sio Y, Say YH, Reginald K, Tim Chew F
J Investig Allergol Clin Immunol 2025; Vol. 35(3)
doi: 10.18176/jiaci.0978
[summary] [PDF full-Text] [Supplemental Materials]

Differences in molecular sensitization profiles between a Spanish and Latin American mite allergic patients
Calzada D, Bartra J, Serrano CD, Riggioni S, Moran E, Maselli JP, Silva DL, Ramirez LF, Pascal M, Carnés J, Valero A
J Investig Allergol Clin Immunol 2025; Vol. 35(2)
doi: 10.18176/jiaci.0968
[summary] [PDF full-Text] [Supplemental Materials]

R-mandelonitrile-lyase, homolog to Pru d 10, is a major peach allergen in peach allergic Spanish population
López-Matas MA, Vílchez-Sánchez F, Álvarez F, Rodriguez-Perez R, Dominguez-Ortega J, Carnes J, Pedrosa M
J Investig Allergol Clin Immunol 2025; Vol. 35(2)
doi: 10.18176/jiaci.0972
[summary] [PDF full-Text]

Investigating Novel Food Sensitization: A Real-Life Prevalence Study of Cricket, Locust, and Mealworm IgE-Reactivity in Naïve allergic Individuals
Scala E, Abeni D, Villella V, ViIlalta D, Cecchi L, Caprini E, Asero R
J Investig Allergol Clin Immunol 2025; Vol. 35(3)
doi: 10.18176/jiaci.0986
[summary] [PDF full-Text] [Supplemental Materials]

Mast Cell Activation Profile and TFH13 Detection Discriminate Food Anaphylaxis Versus Sensitization
Ollé L, García-García L, Ruano M, Bartra J, González-Navarro EA, Pérez M, Roca-Ferrer J, Pascal M, Martín M, Muñoz-Cano R
J Investig Allergol Clin Immunol 2025; Vol. 35(3)
doi: 10.18176/jiaci.0995
[summary] [PDF full-Text] [Supplemental Materials]

Pharmacokinetics and Safety of Bilastine 10 mg/d in Children Aged 2 to 5 Years With Allergic Rhinoconjunctivitis or Urticaria: A Phase 3 Clinical Trial
Majorek-Olechowska B, Slomskis T, Zollerová L, Martín I, Sánchez C, Gilaberte I, Arranz P, on behalf of the BILA-4021/PED Research Group
J Investig Allergol Clin Immunol 2025; Vol. 35(4)
doi: 10.18176/jiaci.1003
[summary] [PDF full-Text] [Supplemental Materials]

Fecal IgE Analyses Reveal a Role for Stratifying Peanut-Allergic Patients
Czolk R, Codreanu-Morel F, de Nies L, Busi SB, Halder R, Hunewald O, Boehm TM, Hefeng FQ, De Beaufort C, Wilmes P, Ollert M, Kuehn A
J Investig Allergol Clin Immunol 2025; Vol. 35(4)
doi: 10.18176/jiaci.1008
[summary] [PDF full-Text] [Supplemental Materials]

Longitudinal Follow-up Reveals Peripheral Immunological Changes Upon Tick Bite in a-Gal-Sensitized Individuals
Swiontek K, Fischer J, Hedin F, Revets D, Riel S, Chakrapani N, Mackenstedt U, Biedermann T, Kuehn A, Cosma A, Ollert M, Hilger C
J Investig Allergol Clin Immunol 2025; Vol. 35(4)
doi: 10.18176/jiaci.1028
[summary] [PDF full-Text] [Supplemental Materials]

Study of Urinary Protein Biomarkers in Hereditary Angioedema
Wu J, Tang X, Zhou N, Wang X, Liu P, Zhang Z, Zhang S, Zhi Y
J Investig Allergol Clin Immunol 2025; Vol. 35(5)
doi: 10.18176/jiaci.1032
[summary] [PDF full-Text] [Supplemental Materials]

Allergic Rhinitis and its Impact on Asthma (ARIA) Classes in MASK-air Users
Sousa-Pinto B, Savouré M, Vieira RJ, Amaral R, Czarlewski W, Bedbrook A, Valiulis A, Kvedariene V, Brussino L, Gemicioglu B, Haahtela T, Klimek L, Kraxner H, Larenas-Linnemann DE, Pfaar O, Regateiro FS, Samolinski B, Taborda-Barata L, Toppila-Salmi S, Ventura MT, Ansotegui IJ, Braido F, Canonica GW, Cecchi L, Cruz AA, Devillier P, Fokkens WJ, Gil-Mata S, Giuliano AFM, Ivancevich JC, Kuna P, Kupczyk M, Louis G, Louis R, Makris M, Morais-Almeida M, Mullol J, Nadif R, Niedoszytko M, Okamoto Y, Ollert M, Papadopoulos NG, Patella V, Pawankar R, Pereira AM, Pétré B, Pham-Thi N, Roche N, Rouadi PW, Sastre J, Scichilone N, Sheikh A, Sova M, Todo-Bom A, Yorgancioglu A, Zidarn M, Anto JM, Zuberbier T, Fonseca JA, Bousquet J
J Investig Allergol Clin Immunol 2025; Vol. 35(5)
doi: 10.18176/jiaci.1047
[summary] [PDF full-Text] [Supplemental Materials]

Causal Effect Between Gut Microbiota, Gut Bacterial Pathway, and Chronic Spontaneous Urticaria: A Large-Scale Bidirectional Mendelian Randomization Analysis
Yao Y, Chen J, Cao H, Lu Z, Shen H, Ji J, Jiao Q
J Investig Allergol Clin Immunol 2025; Vol. 35(6)
doi: 10.18176/jiaci.1054
[summary] [PDF full-Text] [Supplemental Materials]

Validation of an Environmental Exposure Chamber for Assessment of Allergy to Grass Pollen
García-Gutiérrez I, Solórzano-Zepeda C, Sánchez-García V, Ramírez-Mateo E, Antolín-Amérigo D, Zheng Y, Rioja Carrera A, León Hernando I, Hernando Pérez ME, De la Hoz Caballer B
J Investig Allergol Clin Immunol 2025; Vol. 35(5)
doi: 10.18176/jiaci.1036
[summary] [PDF full-Text] [Supplemental Materials]

Dissecting the Sensitization Profiles to Parvalbumins From 12 Freshwater Fish Species to Improve Diagnosis of Fish Allergy
Kalic Kamath T, Djukic T, Kamath SD, Lengger N, Ottersbach S, Uranowska-Kostrubala K, Mladenovic Stokanic M, Park KH, Forstenlechner P, Aumayr M, Lamorte G, Velickovic Cirkovic T, Hemmer W, Breiteneder H, Hafner C
J Investig Allergol Clin Immunol 2025; Vol. 35(6)
doi: 10.18176/jiaci.1069
[summary] [PDF full-Text] [Supplemental Materials]

Practitioner's Corner

Short Communications

Tezepelumab in Patients With Severe Asthma: Response at 3 Months
Miralles-López JC, Andújar-Espinosa R, Bravo-Gutierrez FJ, Cabrejos-Perotti S, Ramírez-Hernández M, Díaz-Chantar C, Pajarón-Fernández MJ, Valverde-Molina J, Pérez-Fernández V, RE-ASGRAMUR GROUP
J Investig Allergol Clin Immunol 2025; Vol. 35(2)
doi: 10.18176/jiaci.1041
[summary] [PDF full-Text] [Supplemental Materials]

Drug-induced Kounis Syndrome: A Retrospective Pharmacovigilance Study from the FAERS and JADER Databases
Li H, Liu Y, Tan L, Hu C, Su L
J Investig Allergol Clin Immunol 2025; Vol. 35(2)
doi: 10.18176/jiaci.1039
[summary] [PDF full-Text] [Supplemental Materials]

A 1-Bag/4-Step Rapid Desensitization Protocol to Reintroduce Agalsidase a in a Patient With Fabry Disease
Jimenez-Rodriguez TW, Soriano Gomis V, Burgos San-José A, Montoyo Antón RA, González Delgado MP, Gallego Velez CP, Ortolano S, Fernández J, Sánchez Martínez R
J Investig Allergol Clin Immunol 2025; Vol. 35(2)
doi: 10.18176/jiaci.1044
[summary] [PDF full-Text] [Supplemental Materials]

Occupational Rhinoconjunctivitis Induced by Flaxseed: Identification of Novel Allergenic Proteins From Cupin, Chaperonin, and Enzyme Families
Gambelunghe A, Chiaradia E, Buratta S, Calzoni E, Tognoloni A, Prosperi E, Giuliani A, Emiliani C, dell’Omo M, Folletti I
J Investig Allergol Clin Immunol 2025; Vol. 35(2)
doi: 10.18176/jiaci.1046
[summary] [PDF full-Text] [Supplemental Materials]

Bioinformatics-Based Prediction of B- and T-Cell Epitopes in R-Mandelonitrile Lyase, a Recently Described Peach Allergen
López-Matas MA, Martín-López L, Vílchez-Sánchez F, Pedrosa M, Rodríguez-Pérez R, Domínguez-Ortega J, Carnés J
J Investig Allergol Clin Immunol 2025; Vol. 35(3)
doi: 10.18176/jiaci.1052
[summary] [PDF full-Text] [Supplemental Materials]

Safety and Efficacy of the First Venom Immunotherapy for Allergy to Vespa velutina nigrithorax: Interim Analysis of the W-STING Study
Carballada F, Parra A, Liñares T, Giangrande N, Varela S, Meijide Á, Castro M, Tabar AI
J Investig Allergol Clin Immunol 2025; Vol. 35(3)
doi: 10.18176/jiaci.1058
[summary] [PDF full-Text] [Supplemental Materials]

Predictive Factors and Optimization of Omalizumab in Chronic Spontaneous Urticaria: A Multicenter Study of 257 Patients
Ceravalls J, Giménez-Arnau AM, Expósito-Serrano V, Fernández Chico N, Lara Moya A, Bielsa I, Ribó P, Mascaró- Hereza B, Bonfill-Ortí M, Spertino J, Serra E, Baliu-Piqué C, Melé-Ninot G
J Investig Allergol Clin Immunol 2025; Vol. 35(3)
doi: 10.18176/jiaci.1053
[summary] [PDF full-Text] [Supplemental Materials]

Generalized Eczema as a Transient Paradoxical Adverse Effect of Dupilumab
Betancor D, Valverde-Monge M, Díaz-Recuero JL, Jo-Velasco ME, Del Pozo V, Sastre J
J Investig Allergol Clin Immunol 2025; Vol. 35(3)
doi: 10.18176/jiaci.1051
[summary] [PDF full-Text] [Supplemental Materials]

Use of a 24-Hour Hotline vs Voicemail for Off-Hour Support During Oral Immunotherapy for Food Allergy
Paradis C, Des Roches A, Elbany C, Braun C, Graham FJ, Samaan K, Labrosse R, Paradis L, Bégin P
J Investig Allergol Clin Immunol 2025; Vol. 35(3)
doi: 10.18176/jiaci.1063
[summary] [PDF full-Text] [Supplemental Materials]

Revisited the Impact of Misdiagnosed Drug Hypersensitivity in Hospitalized Patients: A 10-Year Perspective
Bernaola J, Otal-Buesa M, Barroso B, Valverde-Monge M, Sastre J
J Investig Allergol Clin Immunol 2025; Vol. 35(3)
doi: 10.18176/jiaci.1056
[summary] [PDF full-Text]

Obese Asthma Syndrome: Multiple Inflammatory Patterns and A Key Solution
Bantulà M, García A, Picado C, Arismendi E
J Investig Allergol Clin Immunol 2025; Vol. 35(4)
doi: 10.18176/jiaci.1071
[summary] [PDF full-Text] [Supplemental Materials]

Reduced Prostaglandin D2 Production by Airway Fibroblasts in Nonsteroidal Anti-inflammatory Drug- Exacerbated Airway Disease
Roca-Ferrer J, Machado-Carvalho L, Picado C
J Investig Allergol Clin Immunol 2025; Vol. 35(4)
doi: 10.18176/jiaci.1062
[summary] [PDF full-Text] [Supplemental Materials]

Prioritization of Children With Anaphylaxis in Pediatric Emergency Departments: Results of a National Survey From Spain
Arroabarren Aleman E, de Vicente Jimenez TM, Alvarez García O, Baynova K, Candón Morillo R, Reche Frutos M
J Investig Allergol Clin Immunol 2025; Vol. 35(4)
doi: 10.18176/jiaci.1064
[summary] [PDF full-Text] [Supplemental Materials]

Case Reports

Anaphylaxis Caused by a Mouse Bite in a Laboratory Researcher
Dager-García SA, Germán-Sánchez A, Pineda de la Losa F, Ferrer Franco AM
J Investig Allergol Clin Immunol 2025; Vol. 35(2)
doi: 10.18176/jiaci.1040
[summary] [PDF full-Text] [Supplemental Materials]

ATAK Complex Induced by Ranitidine: A Comprehensive Concept for Cardiac Involvement in Allergic Reactions
Lopez-Raigada A, Vega F, Múgica MV, Lopez-Sanz C, Alfranca A, Blanco C
J Investig Allergol Clin Immunol 2025; Vol. 35(2)
doi: 10.18176/jiaci.1042
[summary] [PDF full-Text]

Measurement of Fecal Calprotectin and Zonulin as Biomarkers in Adults With Fish-Induced Food Protein-Induced Enterocolitis Syndrome
Entrala A, Lluch-Bernal MM, Domínguez-Ortega J, Molero-Luis M, Crespo Sánchez G, Quirce S, Rodríguez-Pérez R
J Investig Allergol Clin Immunol 2025; Vol. 35(3)
doi: 10.18176/jiaci.1049
[summary] [PDF full-Text] [Supplemental Materials]

Basophil Activation Test: An Additional Diagnostic Tool in Vitamin B12 Allergy
Morales-Hidalgo A, Pérez-Montoya M, Cañas JA, Valverde- Monge M, Rodrigo-Muñoz JM, Gil-Martínez M, Gómez- López A, Otal-Buesa M, del Pozo Abejón V, Fernández-Nieto M
J Investig Allergol Clin Immunol 2025; Vol. 35(2)
doi: 10.18176/jiaci.1048
[summary] [PDF full-Text] [Supplemental Materials]

Hidden Dangers of Oral Contrast Media: Delayed Hypersensitivity to Sodium Amidotrizoate and Meglumine Amidotrizoate (Gastrografin)
Pardo-Manrique V, Amat-Samaranch V, Pascal M, Loli-Ausejo D, Sánchez-Fernández MC, Ruano-Zaragoza M
J Investig Allergol Clin Immunol 2025; Vol. 35(3)
doi: 10.18176/jiaci.1055
[summary] [PDF full-Text] [Supplemental Materials]

Anaphylaxis Induced by Milk Thistle (Silybum marianum) Seed Ingestion: A Case Report
Planas-Vinos M, Sala-Cunill A, Luengo O, Castillo Fernandez M, Galvan-Blasco P, Cardona V, Guilarte M, Labrador-Horrillo M, Gil-Serrano J
J Investig Allergol Clin Immunol 2025; Vol. 35(3)
doi: 10.18176/jiaci.1057
[summary] [PDF full-Text]

Sensitization to Pru p 7 in Peach-Allergic Patients Sensitized to Pru p 3 in Areas of High Exposure to Cypress Pollen
Tomás-Pérez M, Vera-Berrios RN, Casas-Saucedo R, Galleani C, González-Bravo L, Gonzalo-Fernández A, González-Pérez A, Rodríguez-Mazariego E, Ruano-Zaragoza M, Zambrano-Ibarra G, Bartra-Tomás J
J Investig Allergol Clin Immunol 2025; Vol. 35(4)
doi: 10.18176/jiaci.1065
[summary] [PDF full-Text] [Supplemental Materials]

Successful Desensitization to Ramucirumab in Signet-Cell Gastric Adenocarcinoma
Villarreal-González RV, Madrazo-Morales M, Sáenz-Cantú KS, García Rosas C, Burguete-Torres A, Vidal-Gutiérrez O
J Investig Allergol Clin Immunol 2025; Vol. 35(4)
doi: 10.18176/jiaci.1066
[summary] [PDF full-Text]

Letters to the Editor

Occupational Asthma and Rhinoconjunctivitis due to Soybean in a Bakery Worker
Özdemir Ö
J Investig Allergol Clin Immunol 2025; Vol. 35(2)
doi: 10.18176/jiaci.1035
[summary] [PDF full-Text]

Fatal CAEBV-Associated Vasculitis in ICF Syndrome Type 2
Shigemura T, Kobayashi N, Uehara T, Nakazawa Y
J Investig Allergol Clin Immunol 2025; Vol. 35(2)
doi: 10.18176/jiaci.1037
[summary] [PDF full-Text] [Supplemental Materials]

Effectiveness of Biologics in Patients With Severe Asthma and Psychiatric Comorbidities
Mascaró-Hereza B, Loli-Ausejo D, Valero A, Arismendi E, Bobolea I
J Investig Allergol Clin Immunol 2025; Vol. 35(2)
doi: 10.18176/jiaci.1034
[summary] [PDF full-Text]

Component-Based Assessment of the Main Allergens in Honeybee Venom in a Spanish Allergic Population
Carballada González F, Abel-Fernández E, González Guzmán LA, Pineda de la Losa F
J Investig Allergol Clin Immunol 2025; Vol. 35(3)
doi: 10.18176/jiaci.1050
[summary] [PDF full-Text] [Supplemental Materials]

ISO 9001:2015 Certification of the Allergy Laboratory
Caballero ML, Carpio-Hernández D, Parra P, Giraldo-Sánchez JC, Rodríguez-Álvarez M, Quirce S
J Investig Allergol Clin Immunol 2025; Vol. 35(2)
doi: 10.18176/jiaci.1045
[summary] [PDF full-Text]

Ongoing Concerns With Honeybee Venom Immunotherapy
Khan S
J Investig Allergol Clin Immunol 2025; Vol. 35(3)
doi: 10.18176/jiaci.1060
[summary] [PDF full-Text]