Objective:
This study aimed to
evaluate the
clinical effi cacy
and antibody
response changes
after specific
immunotherapy (SIT)
using
Dermatophagoides
pteronyssinus (Dpt)
allergens with or
without bacterial
extracts in
Brazilian mite-atopic
patients.
Methods: One-hundred
patients with
allergic rhinitis
were selected for a
randomized double-blind,
placebo-controlled
trial and
distributed into 4
groups: Dpt (Dpt
allergen extract),
Dpt + MRB (Dpt
allergen plus mixed
respiratory
bacterial extracts),
MRB (MRB extract
only) and placebo.
Rhinitis symptom and
medication scores;
skin prick test (SPT)
to Dpt extract; and
serum immunoglobulin
(Ig) E, IgG4, and
IgG1 levels to Dpt,
Der p 1, and Der p 2
allergens were
evaluated before and
after a year of
treatment.
Results:
After 1 year, the
SPT response was
reduced in the Dpt
group (P = .03),
whereas IgE levels
to Der p 2 decreased
only in the Dpt (P =
.048) and Dpt + MRB
(P = .005) groups.
IgG4 and IgG1 levels
to Dpt and Der p 1
increased in the Dpt
group (P < .05),
whereas in the Dpt +
MRB group the IgG1
level only increased
to Dpt (P = .001)
and the IgG4 only
increased to Der p 1
(P = .049). IgE
levels to Dpt
decreased only in
the MRB (P= .005)
and Dpt + MRB (P =
.001) groups.
Rhinitis symptom and
medication scores
fell in all groups,
including the
placebo group (P <
.001).
Conclusions:
SIT using Dpt
extract alone was
effective in
reducing SPT
response and IgE
levels to Der p 2
allergen, while
bacterial extracts
induced decreases in
IgE levels to whole
Dpt extract. However,
only groups
receiving Dpt
allergen had higher
levels of IgG1 and
IgG4 to Dpt and Der
p 1 after a year of
treatment.
Key words:
Allergen-specific
immunotherapy.
Dermatophagoides
pteronyssinus. Der p
1. Der p 2.
Immunoglobulin (Ig)
E antibody. IgG1 and
IgG4 subclasses. |