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A del Cuvillo,1 J
Sastre,2,3 J Montoro,4 I Jáuregui,5
I Dávila,6 M Ferrer,7 J Bartra,8,3
J Mullol,9,3 A Valero8,3 |
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1 Clínica Dr. Lobatón, Cádiz, Spain
2 Servicio de Alergia, Fundación Jiménez Díaz, Madrid,
Spain
3 Centro de Investigación Biomédica en Red de
Enfermedades Respiratorias (CIBERES)
4 Unidad de Alergia, Hospital La Plana, Villarreal (Castellón),
Spain
5 Servicio de Alergología, Hospital de Basurto, Bilbao,
Spain
6 Servicio de Inmunoalergia, Hospital Universitario,
Salamanca, Spain
7 Departamento de Alergia e Inmunología Clínica, Clínica
Universidad de Navarra, Pamplona, Spain
8 Unitat dAl.lèrgia, Servei de Pneumologia i Al.lèrgia
Respiratòria, Hospital Clinic (ICT), Barcelona, Spain
9 Unitat de Rinologia & Clínica de lOlfacte, Servei
dOto-rino-laringologia, Hospital Clínic Immunoal.lèrgia
Respiratòria Clínica i Experimental, IDIBAPS. Barcelona,
Spain |
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Abstract |
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Allergic
conjunctivitis is
the most common form
of ophthalmological
allergy. Eye
symptoms are one of
the main and most
frequent reasons for
consultation among
patients with
allergic
rhinoconjunctivitis,
which in turn is the
most common reason
for visiting the
allergologist,
according to the
Alergológica 2005
study. Itching is
the key symptom of
allergic
conjunctivitis, and
its relief is the
principal objective
of the broad range
of treatment options
available. Topical
antihistamines with
multiple actions
(mast cell
stabilization, and
antiinflammatory and
antihistaminic
actions) are
probably the best
treatment option,
thanks to their
rapid action, safety
and convenience of
use. However,
oral antihistamines
(preferentially
second generation
drugs) can also play
an important role,
since they are of
established efficacy
and offer adequate
treatment of the
nasal symptoms that
tend to accompany
the ocular
manifestations of
allergic
rhinoconjunctivitis.
Models of allergic
conjunctivitis are
useful for
investigational
purposes and for
advancing our
knowledge of
allergic reactions.
Advances in the
study of
the physiopathology
of ocular allergy
allow us to
introduce new
therapeutic options
for the management
of such allergic
reactions, thanks to
the findings derived
from models of this
kind. The present
review provides an
update to the
published data on
allergic
conjunctivitis and
the current role of
both topical and
ocular
antihistamines in
treating the
disorder.
Key words:
Allergic
conjunctivitis,
topical
antihistamines, oral
antihistamines,
ocular allergy.
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