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N Kawamoto,1,2 T Fukao,1
H Kaneko,1,3 K Hirayama,1 S
Sakurai,1 T Arai,1 M Kondo,1
M Kawamoto,1 E Matsui,1 T
Teramoto,1 K Kasahara,1 C Bai,1
G Zhang,1 K Omoya,1 E Matsukuma,1
M Morimoto,2 H Suzuki,1 Y Aoki,1
T Kimura,2 M Nada,1 H Morita,3
T Tokumi,1 M Takemura,4 M
Seishima,4 M Shiraki,5 S Iwasa,5
N Kondo1 |
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1Department of Pediatrics, Graduate
School of Medicine, Gifu University, Gifu, Japan
2Neonatal Intensive Care Unit, Gifu University Hospital,
Gifu, Japan
3Department of Clinical Research, National Hospital
Organization, Nagara Medical Center, Gifu, Japan
4Department of Informative Clinical Medicine, Graduate
School of Medicine, Gifu University, Gifu, Japan
5Iwasa Maternity, Gifu, Japan |
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Abstract |
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Background:
The pathogenic
mechanisms of atopic
dermatitis (AD) and
recurrent wheezing (RW)
during infancy are
not fully
understood.
Objective: We
evaluated
immunological
markers associated
with AD and RW
during infancy.
Methods: We
followed a cohort
(n=314) from birth
to 14 months of age.
Some of the
participants
underwent a physical
examination and
blood test at 6 and
14 months of age.
Univariate and
multivariate
logistic regression
analysis and
receiver operating
characteristic curve
analysis were
performed to find
which immunological
markers could be
risk factors for AD
and RW.
Results: Of
16 immunological
markers found in
cord blood, only
immunoglobulin (Ig)
E was associated
with AD at 6 months
of age (adjusted OR
[aOR], 1.607). None
of the markers was
associated with AD
or RW at 14 months
of age. Of 23
immunological
markers at 6 months
of age, total IgE (aOR,
1.018) and
sensitization to egg
white (aOR, 23.246)
were associated with
AD at 14 months of
age.
Phytohemagglutinin (PHA)induced
production of
interleukin (IL) 4
from peripheral
blood mononuclear
cells (PBMCs) (aOR,
1.043) was
associated with RW
at 14 months of age.
Conclusion:
Cord blood IgE was a
risk factor for AD
at 6 months of age.
Total IgE and
sensitization to egg
white at 6 months of
age were risk
factors for AD at 14
months of age. PHA-induced
IL-4 production in
PBMCs at 6 months of
age was a risk
factor for RW at 14
months of age.
Key words:
Birth cohort.
Infants. Cord blood.
Atopic dermatitis.
Recurrent wheezing.
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