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Background:
Nasal polyposis (NP)
is a chronic
inflammatory disease
that is frequently
associated with
allergy and asthma.
Corticosteroid
therapy and surgical
removal of polyps
are the 2 most
common treatment
strategies for NP.
Various allergic and
inflammatory
mediators are
thought to play a
major role in the
pathophysiology of
this disorder. The
CD14 gene is
located on
chromosome 5q31-32,
which is considered
a critical region
for several allergic
and atopic diseases,
including asthma.
Consequently,
variations in
CD14 could have
functional effects
on the etiology and
severity of allergy
and asthma. The aim
of this study was to
investigate the
association between
the polymorphism
C159T in the
CD14 gene of
patients with NP and
controls.
Methods: The
study population
comprised 106
patients with NP
diagnosed based on
computed tomography
scan of the
paranasal sinus,
endoscopy, and
histological
examination.
Findings were
compared with those
from 87 controls.
The frequency of
C159T was
determined using
polymerase chain
reaction-restriction
fragment length
polymorphism
analysis. DNA was
extracted using the
salting out
technique.
Results: A
significant
association was
observed between
C159T and NP
(P=.04). Patients
with the CC genotype
at position 159 of
the CD14
promoter region had
an increased risk of
asthma (OR, 3.83,
95%CI, 0.99-13.91;
P<.02). However, we
did not find an
association between
the distribution of
C159T and serum
immunoglobulin E
level.
Conclusions:
A genetic variation
in the CD14 promoter
might play a role in
the pathogenesis of
NP and in the
incidence of asthma.
Key words:
Nasal polyps.
CD14
polymorphism.
Allergy. Asthma. |
