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R Nasiri,1,2,3 A Akbar
Amirzargar,4 M Movahedi,1 A
Hirbod-Mobarakeh,4,5,6 E Farhadi,4
N Behniafard,1 M Tavakkol,1 B
Ansaripour,4 B Moradi,4 A Zare,2
N Rezaei1,4,5 |
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1Pediatrics Center of Excellence, Children's
Medical Center, Tehran University of Medical Sciences,
Tehran, Iran
2Immunology, Asthma and Allergy Research
Institute, Tehran University of Medical Sciences,
Tehran, Iran
3Department of Pediatrics, Kurdistan
University of Medical Sciences, Sanandaj, Iran
4Molecular Immunology Research Center; and
Department of Immunology, School of Medicine, Tehran
University of Medical Sciences, Tehran, Iran
5Research Center for Immunodeficiencies,
Children's Medical Center, Tehran University of Medical
Sciences, Tehran, Iran
6Students Scientifi c Research Center,
Tehran University of Medical Sciences, Tehran, Iran |
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Abstract |
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Background:
Allergic rhinitis is
a complex polygenic
disorder of the
upper respiratory
tract. Given that
proinflammatory
cytokines such as
tumor necrosis
factor (TNF) and
interleukin (IL) 1
seem to play a role
in the development
of allergic
rhinitis, we
evaluated the
associations between
various
single-nucleotide
polymorphisms (SNPs)
of the TNF
and IL1 genes
in a case-control
study.
Methods: The
study population
comprised 98
patients with
allergic rhinitis.
Genotyping was
performed using
polymerase chain
reaction with
sequence-specific
primers for 2
TNFA promoter
variants (rs1800629
and rs361525), 1
variant in the
promoter region of
IL1A
(rs1800587), 2 SNPs
in the IL1B
gene (rs16944 and
rs1143634), 1
variant in the
IL1 receptor
(rs2234650), and 1
in IL1RA
(rs315952).
Results:
Patients who were
homozygous for the T
allele of rs16944 in
IL1B had an
8.1-fold greater
risk of allergic
rhinitis than those
with the C allele.
In TNFA, a
significant
relationship was
also detected
between rs1800629
and rs361525 and
allergic rhinitis.
Except for rs1800587
in IL1A and
rs315952 in IL1RA,
significant
differences were
found between the
patient and control
groups for all other
SNPs.
Conclusions:
We found that
allelic variants in
the TNFA and
IL1 genes
were not only
associated with the
risk of developing
allergic rhinitis,
but also affected
disease course and
severity.
Key words:
Allergic rhinitis.
Genetic
susceptibility.
Single-nucleotide
polymorphism.
Proinflammatory
cytokines. Tumor
necrosis factor.
Interleukin 1
family. |
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