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CTLA-4 Expression in CD4+ T Cells From Patients With LRBA Deficiency and Common Variable Immunodeficiency With No Known Monogenic Disease

Azizi G1,2,3, Jamee M4, Yazdani R2, Bagheri Y5,6, Fayyaz F4, Jadidi- Niaragh F7,8, Abolhassani H2,9, Aghamohammadi A2

1Non-Communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran
2Research Center for Immunodeficiencies, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran
3Primary Immunodeficiency Diseases Network (PIDNet), Universal Scientific Education and Research Network (USERN), Tehran, Iran
4Student Research Committee, Alborz University of Medical Sciences, Alborz, Iran
5Clinical Research Development Unit (CRDU), 5 azar Hospital, Golestan University of Medical Sciences, Gorgan, Iran
6Department of Allergy and Clinical Immunology, Iran University of Medical Sciences, Tehran, Iran
7Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
8Department of Immunology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
9Division of Clinical Immunology, Department of Laboratory Medicine, Karolinska Institute at Karolinska University Hospital Huddinge, Stockholm, Sweden

J Investig Allergol Clin Immunol 2018; Vol 28(6) : 422-424
doi: 10.18176/jiaci.0302

Key words: Common variable immunodeficiency, LRBA deficiency, CTLA-4