Jiaci

Kuruvilla M, et al.

J Investig Allergol Clin Immunol 2019; Vol. 29(5): 349-356

doi: 10.18176/jiaci.0320

3. Katelaris CH, Bielory L. Evidence-based study design in ocular

allergy trials. Curr Opin Allergy Clin Immunol. 2008;8(5):484-

4. Wuthrich B, Brignoli R, Canevascini M, Gerber M.

Epidemiological survey in hay fever patients: symptom

prevalence and severity and influence on patient management.

Schweiz Med Wochenschr. 1998;128(5):139-43.

5. Blaiss MS. Allergic rhinoconjunctivitis: burden of disease.

Allergy Asthma Proc. 2007;28(4):393-7.

6. Ono SJ, Abelson MB. Allergic conjunctivitis: update on

pathophysiology and prospects for future treatment. J Allergy

Clin Immunol. 2005;115(1):118-22.

7. Hoffmann-Sommergruber K, Ferreira ED, Ebner C, Barisani

T, Korninger L, Kraft D, et al. Detection of allergen-specific

IgE in tears of grass pollen-allergic patients with allergic

rhinoconjunctivitis. Clin Exp Allergy. 1996;26(1):79-87.

8. Anderson DF, MacLeod JD, Baddeley SM, Bacon AS, McGill

JI, Holgate ST, et al. Seasonal allergic conjunctivitis is

accompanied by increased mast cell numbers in the absence

of leucocyte infiltration. Clin Exp Allergy. 1997;27(9):1060-6.

9. Katelaris CH. Ocular allergy in the Asia Pacific region. Asia Pac

Allergy. 2011;1(3):108-14.

10. Virchow JC, Kay S, Demoly P, Mullol J, Canonica W, Higgins

V. Impact of ocular symptoms on quality of life (QoL), work

productivity and resource utilisation in allergic rhinitis

patients--an observational, cross sectional study in four

countries in Europe. J Med Econ. 2011;14(3):305-14.

11. Bernstein JA, Singh U. Neural Abnormalities in Nonallergic

Rhinitis. Curr Allergy Asthma Rep. 2015;15(4):18.

12. Bonini S, Bonini S, Schiavone M, Centofanti M, Allansmith

MR, Bucci MG. Conjunctival hyperresponsiveness to ocular

histamine challenge in patients with vernal conjunctivitis. J

Allergy Clin Immunol. 1992;89(1 Pt 1):103-7.

13. Ciprandi G, Buscaglia S, Pesce GP, Bagnasco M, Canonica

GW. Ocular challenge and hyperresponsiveness to histamine

in patients with allergic conjunctivitis. J Allergy Clin Immunol.

1993;91(6):1227-30.

14. Leonardi A, Piliego F, Castegnaro A, Lazzarini D, La Gloria

Valerio A, Mattana P, et al. Allergic conjunctivitis: a cross-

sectional study. Clin Exp Allergy. 2015;45(6):1118-25.

15. Bielory L. Vasomotor (perennial chronic) conjunctivitis. Curr

Opin Allergy Clin Immunol. 2006;6(5):355-60.

16. Belmonte C, Aracil A, Acosta MC, Luna C, Gallar J. Nerves and

sensations from the eye surface. Ocul Surf. 2004;2(4):248-53.

17. Sukhotinsky I, Ben-Dor E, Raber P, Devor M. Key role of the

dorsal root ganglion in neuropathic tactile hypersensibility.

Eur J Pain. 2004;8(2):135-43.

18. Lieu TM, Myers AC, Meeker S, Undem BJ. TRPV1 induction

in airway vagal low-threshold mechanosensory neurons by

allergen challenge and neurotrophic factors. Am J Physiol

Lung Cell Mol Physiol. 2012;302(9):L941-8.

19. Van Gerven L, Alpizar YA, Wouters MM, Hox V, Hauben

E, Jorissen M, et al. Capsaicin treatment reduces nasal

hyperreactivity and transient receptor potential cation channel

subfamily V, receptor 1 (TRPV1) overexpression in patients with

idiopathic rhinitis. J Allergy Clin Immunol. 2014;133(5):1332-

9, 9 e1-3.

20. McGarvey LP, Butler CA, Stokesberry S, Polley L, McQuaid S,

Abdullah H, et al. Increased expression of bronchial epithelial

transient receptor potential vanilloid 1 channels in patients

with severe asthma. J Allergy Clin Immunol. 2014;133(3):704-

12 e4.

21. Wouters MM, Balemans D, Van Wanrooy S, Dooley J, Cibert-

Goton V, Alpizar YA, et al. Histamine Receptor H1-Mediated

Sensitization of TRPV1 Mediates Visceral Hypersensitivity

and Symptoms in Patients With Irritable Bowel Syndrome.

Gastroenterology. 2016;150(4):875-87 e9.

22. Raemdonck K, de Alba J, Birrell MA, Grace M, Maher SA,

Irvin CG, et al. A role for sensory nerves in the late asthmatic

response. Thorax. 2012;67(1):19-25.

23. O'Hanlon S, Facer P, Simpson KD, Sandhu G, Saleh HA,Anand P.

Neuronal markers in allergic rhinitis: expression and correlation

with sensory testing. Laryngoscope. 2007;117(9):1519-27.

24. Sarin S, Undem B, Sanico A, Togias A. The role of the nervous

system in rhinitis. J Allergy Clin Immunol. 2006;118(5):999-

1016.

25. Rogerio AP, Andrade EL, Calixto JB. C-fibers, but not the

transient potential receptor vanilloid 1 (TRPV1), play a role in

experimental allergic airway inflammation. Eur J Pharmacol.

2011;662(1-3):55-62.

26. Azimi E, Reddy VB, Pereira PJS, Talbot S, Woolf CJ, Lerner EA.

Substance P activates Mas-related G protein-coupled receptors

to induce itch. J Allergy Clin Immunol. 2017;140(2):447-53

e3.

27. Bresciani M, Laliberte F, Laliberte MF, Gramiccioni C, Bonini S.

Nerve growth factor localization in the nasal mucosa of patients

with persistent allergic rhinitis. Allergy. 2009;64(1):112-7.

28. Raap U, Braunstahl GJ. The role of neurotrophins in the

pathophysiology of allergic rhinitis. Curr Opin Allergy Clin

Immunol. 2010;10(1):8-13.

29. Bonini S, Lambiase A, Bonini S, Angelucci F, Magrini L, Manni

L, et al. Circulating nerve growth factor levels are increased in

humans with allergic diseases and asthma. Proc Natl Acad Sci

U S A. 1996;93(20):10955-60.

30. Acosta MC, Luna C, Quirce S, Belmonte C, Gallar J. Changes

in sensory activity of ocular surface sensory nerves during

allergic keratoconjunctivitis. Pain. 2013;154(11):2353-62.

31. Chen CY, Bonham AC, Schelegle ES, Gershwin LJ, Plopper CG,

Joad JP. Extended allergen exposure in asthmatic monkeys

induces neuroplasticity in nucleus tractus solitarius. J Allergy

Clin Immunol. 2001;108(4):557-62.

32. Undem BJ, Hubbard WC, Christian EP, Weinreich D. Mast cells

in the guinea pig superior cervical ganglion: a functional and

histological assessment. J Auton Nerv Syst. 1990;30(1):75-87.

33. Alenmyr L, Hogestatt ED, Zygmunt PM, Greiff L. TRPV1-

mediated itch in seasonal allergic rhinitis. Allergy.

2009;64(5):807-10.

34. Gelardi M, Leo ME, Quaranta VN, Iannuzzi L, Tripodi S,

Quaranta N, et al. Clinical characteristics associated with

conjunctival inflammation in allergic rhinoconjunctivitis. J

Allergy Clin Immunol Pract. 2015;3(3):387-91 e1.

35. Cevikbas F, Wang X, Akiyama T, Kempkes C, Savinko T, Antal A,

et al. A sensory neuron-expressed IL-31 receptor mediates T

helper cell-dependent itch: Involvement of TRPV1 and TRPA1.

J Allergy Clin Immunol. 2014;133(2):448-60.

36. Akiyama T, Carstens E. Neural processing of itch. Neuroscience.

2013;250:697-714.

37. Mantelli F, Micera A, Sacchetti M, Bonini S. Neurogenic

inflammation of the ocular surface. Curr Opin Allergy Clin

Immunol. 2010;10(5):498-504.

355